The working hypothesis of this proposal is that a membrane- bound inhibitor of phosphatidylcholine biosynthesis (a potential membrane anchor) in platelets is released upon activation and modulates the aggregation process. The proposed studies focus on the relationship of PAF (platelet activating factor) release to the biosynthetic process. Since the anchorage of PAF will be studied we will attempt to induce PAF release in order to examine the biosynthetic process. We will first look at the biosynthetic process in terms of its effects on activity of various enzymes involved and metabolic enzyme release during platelet activation. We will then look at a number of other effects of PAF on platelets (platelet-neutrophil interactions, stability of phospholipid profiles, collagen binding, cyclic AMP levels, metabolism of prostaglandins) to see if it is due to the action of PAF as an anchor. The anchor will be studied as follows: PAF-induced release of a membrane bound phospholipid. PAF- induced translocation of the biosynthetic enzyme in intact platelets. PAF-induced release of the anchoring enzyme itself.New Balance Athlete of the Year: Dallas Cowboys Running Back Joseph Randle
New Balance's Athlete of the Year award is a slam dunk. Dallas Cowboys running back Joseph Randle takes home the award, as his performance this season has been unmatched among players in recent memory.
It took 24 months of grinding, but Joseph Randle is finally being recognized by one of the most prestigious awards in the game.
This season, a “slow and steady” Randle has emerged, transforming himself into one of the NFL’s best running backs, a role that he hadn’t been in since entering the league.
Randle’s career hasn’t been perfect. When he entered the league, the former Oklahoma State standout was expected to develop into the next Emmitt Smith. Through his first two seasons in the NFL, he failed to live up to that potential, but this season has seen a dramatic turn-around, and now it is starting to pay off.
This season has been a career-best for Randle, who leads the NFL in rushing yards per game (101.9).
His position change to running back has been a key to his rising production. According to Pro Football Focus 0b46394aab